Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

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Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging.

Astrocytes and microglia become reactive under most brain pathological conditions, making this neuroinflammation process a surrogate marker of neuronal dysfunction. Neuroinflammation is associated with increased levels of translocator protein 18 kDa (TSPO) and binding sites for TSPO ligands. Positron emission tomography (PET) imaging of TSPO is thus commonly used to monitor neuroinflammation in...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2012

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.1487-12.2012